About

The focus of the laboratory is to study diseases relevant to Allergy & Immunology. The primary model of investigation has involved human studies, however, animal models are also used when appropriate.

The Zuraw lab consists of 1,000 square feet of wet lab space in the Stein Clinical Research Building, including two offices. The laboratory utilizes an open design, promoting interactions with nearby groups. There is easy access to clinical space, the CTRI, and animal facilities. The Angioedema Center will have over 3,300 square feet of clinical space for both patient care and clinical research studies. The laboratory welcomes trainees at all levels, including undergraduate and graduate students as well as post-doctoral fellows.

The Zuraw lab conducts research in two separate areas, angioedema and asthma. Angioedema studies are focused on bradykinin-mediated swelling, investigating genetic determinants of angioedema severity, the role of bradykinin receptors in swelling, and the cell biology of C1 inhibitor deficiency. In collaboration with the US HAEA Angioedema Center, of which Dr. Zuraw is Director, the laboratory is studying improved assays for the diagnosis of angioedema. Asthma studies focus on the role of the airway epithelial cell in inflammatory airway disease. The laboratory is studying the impact of glucocorticoid-induced leucine zipper (GILZ) in down-regulating airway inflammation as well as the role of B2 and B1 bradykinin receptors as well as transient receptor potential channels in allergic airway inflammation.