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Division of Allergy & Immunology Division of Allergy & Immunology
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Research

Allergic Disease Research

The Doherty lab studies the involvement of group 2 innate lymphoid cells (ILC2s) in allergic diseases including: asthma, allergic rhinitis, chronic rhinosinusitis, aspirin-exacerbated respiratory disease (AERD), and eosinophilic esophagitis (EoE).

Research Highlights

  • November 2023, study entitled “Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD” was published in the Journal of Allergy and Clinical Immunology.
  • July 2022, study entitled “RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation an inflammation partially through CysLT1R” was published in Nature Communications.
  • July 2017, study entitled “Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease” was published in the Journal of Allergy and Clinical Immunology. This article was highlighted in the journal’s Editor’s Choice feature.
  • August 2017, study entitled “Leukotriene C4 potentiates IL-33-induced group 2 innate lymphoid cell activation and lung inflammation” was published in the Journal of Immunology.
  • July 2013, study entitled “Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production” was published in the Journal of Allergy and Clinical Immunology.
  • May 2011, study entitled “The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling” was published in Nature Medicine.

Funding for the Doherty lab has been Provided by: 
The National Institute of Allergy and Infectious Disease (NIAID), the Veterans Affairs Medical Center (VA), the American Lung Association (ALA), the American Academy of Allergy, Asthma and Immunology (AAAAI), and UCSD CTRI. 

Collaborations/Collaborators

UCSD
  • David Broide, M.B, Ch.B
  • Pam Taub, M.D., FACC, FASPC
  • Caroline Nievergelt, Ph.D.
UCSD Sinus Center:
  • Sandra Christiansen, M.D.
  • Adam DeConde, M.D.
  • Bruce Zuraw, M.D.
  • Alex Kim, M.D.
  • Carol Yan, M.D.
  • Praveen Akuthota, M.D.
Scripps Clinic: Andrew White, M.D.
The Scripps Research Institute: Peter Vanderklish, Ph.D.
The La Jolla Institute for Allergy and Immunology: Michael Croft, Ph.D.