Dr. Lori Broderick
Dr. Lori Broderick is an Associate Professor of Pediatrics in the Division of Allergy, Immunology, Rheumatology, and Kawasaki Disease, and Director of the Recurrent Fever Disorders Clinic at Rady Children’s Hospital. The Broderick Lab investigates molecular mechanisms of immunodysregulation in rare, pediatric disorders.
About the Lab
The Broderick lab focuses on the genetics and molecular pathophysiology of rare disorders in pediatrics. Using human genetics, molecular biology, and translational studies, we strive to understand the link between genetic changes and disease, to ultimately identify new approaches for therapy.
Read More About the LabResearch Highlights
- From gene to therapy, novel disease mechanisms published in the New England Journal of Medicine: Baghdassarian, et al. (2023). Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome
- Discovering new disease mechanisms: recent findings published in Nature Communications: Broderick L, Yost S, et al. (2019) Mutations in topoisomerase IIβ result in a B cell immunodeficiency
- Linking patient care and basic science research: Luu I, Sharma A, et al (2020) Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome